Sildenafil, available to by as Sildenafil Citrate , and under innumerable other trade names, is a drug used to combat e.d. and pulmonary arterial hypertension (PAH).Sildenafil Citrate can be used to combat e.d., the inability to succesfully achieve and/or maintain an erection of the male member that is adequate for sexual sex.

In February 2007, an announcetwas made that Boots the Chemist would trial over the counter sales of Sildenafil Citrate in stores in Manchester, England. Males aged between 30 and 65 would be able to buy four tablets after a consultation with a pharmacist.

Sildenafil is metabolised by liver enzymes and let out by both the liver and kidneys. If consumed with a high-fat meal, absorption is reduced; the amount of time it takes to reach the maximum plasma concentration increases to up to one hour, and the maximum concentration itself is decreased by nearly one-third.

Anyone experiencing cardio-vascular problems including dizziness, chest or arm pain, and nausea when taking part in sexual activity after taking Sildenafil Citrate may stop the encounter. As well as this they may also not take Sildenafil Citrate again until they have discussed the episode with their healthcare provider.

Sildenafil Citrate is a vasodilator, a drug that has the effect of dilating the blood vessels. It works by improving blood circulation to the male member, and by enhancing the effects of nitric oxide, the agent that relaxes the smooth muscle of the male member and regulates blood vessels during sexual stimulation, allowing the male member to become engorged and succesfully achieve an erection.

Males who are taking Sildenafil Citrate and inadvertently or intentionally take a medication with nitrates could suffer from life-threatening hypotension-a severe drop in blood pressure.