Sildenafil, sold as Generic Sildenafil , and under a number of other trade names, is a drug used to deal with e.d. and pulmonary arterial hypertension (PAH).Generic Sildenafil treats e.d., the inability to succesfully achieve and/or maintain an erection of the male member that is adequate for sexual intercourse.

The generic Generic Sildenafil Sildenafil compound was developed by a collection of pharmaceutical chemists working at Pfizer’s Sandwich, Kent, testing facility in England. It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a symptom of ischaemic heart disease). The initial clinical tests were conducted in Morriston Hospital in Swansea. Phase I clinical tests suggested that the drug had little effect on angina, but that it could induce marked penile erections. Pfizer therefore decided to market it for e.d., instead of angina. The drug was patented in 1996, approved for use in e.d. by the US Food and drug Administration on March 27, 1998, becoming the initial oral treatment approved to deal with e.d. in the United States, and offered for sale in the United States later that year.It soon became a great success: yearly sales of Generic Sildenafil in the period 1999-2001 exceeded $1 billion.

Sildenafil is metabolised by liver enzymes and excreted by both the liver and kidneys. If taken with a high-fat meal, absorption is lessened; the amount of time it takes to reach the maximum plasma concentration increases by around one hour, and the maximum concentration itself is decreased by nearly one-third.

As sexual activity can stress the heart, men who have heart issues must check with their physician to see if sexual activity is recommended. Generic Sildenafil in some circumstances can set off temporary hypotension (low blood pressure) and is known to improve heart function nerve activity, so it is given with caution in men with a history of heart attack, artherosclerosis, angina, arrhythmia, and chronic low blood pressure issues.

Generic Sildenafil in some circumstances can also interact with other prescription and over-the-counter (OTC) medicines, either inflating or deflating the intended therapeutic effects of one or both drugs. Some drugs that have a known interaction with Generic Sildenafil include the protease inhibitor ritonavir and the antibiotic erythromycin. For this reason, it is vital that men who are given Generic Sildenafil let their healthcare givers know all the medicines they are taking.

Priapism, a sore and prolonged erection that lasts for two to six hours, is a unusual but potentially serious side effect of Generic Sildenafil . As prolonged erection can permanently damage the tissues of the male member, anyone who experiences an erection lasting over four hours must call a healthcare professional immediately.